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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

《化学科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 276-279 doi: 10.1007/s11705-014-1426-x

摘要： The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze our current abilities, and design the future technologies that will propel us to achieve the next level of drug delivery technologies. History shows that the first generation (1G) of drug delivery research during 1950–1980 was quite productive, while the second generation (2G) technologies developed during 1980–2010 were not as prolific. The ultimate goal of drug delivery research is to develop clinically useful formulations to treat various diseases. Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological barriers. The engineering approach has a limit in solving the problem, if biological difficulties are not clearly identified and understood. The third generation (3G) drug delivery systems will have to focus on understanding the biological barriers so that they can be overcome by engineering manipulation of the drug delivery systems. Advances in the next 30 years will be most accelerated by starting open dialogues without any preconceived ideas on drug delivery technologies. The new generation of drug delivery scientists needs to be aware of the successes and limitations of the existing technologies to design the new technologies for meaningful advances in the future.

关键词： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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Understanding barriers to BIM implementation: Their impact across organizational levels in relation to

Sander SIEBELINK, Hans VOORDIJK, Maaike ENDEDIJK, Arjen ADRIAANSE

《工程管理前沿（英文）》 2021年 第8卷 第2期   页码 236-257 doi: 10.1007/s42524-019-0088-2

摘要： This multiple case study of a contracting firm contributes to understanding the barriers that organizations face during the implementation of building information modeling (BIM) by providing insights into the impact of these barriers across different organizational levels (i.e., from top management to project teams) and by relating these barriers to different degrees of BIM maturity. First, we observe the dominance of barriers related to the motivation, competence, and time capacity of people across all levels of an organization. Second, the cluster of barriers at the middle-management level highlights the important role of this level in reducing these barriers. Third, only those cases with a low level of BIM maturity have struggled with lack of top management support, thereby highlighting the importance of such support in achieving BIM maturity growth. High BIM maturity situations are more prone to externally oriented barriers in attempting to further leverage the benefits of BIM. Our study provides insights on where to focus BIM implementation measures and how to enhance organizational BIM maturity.

关键词： building information modeling     implementation barriers     maturity     organizational levels    

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Avoiding barriers in control of mowing robot

QIU Bai-jing, QIAN Guo-hong, XIANG Zhong-ping, LI Zuo-peng

《机械工程前沿（英文）》 2006年 第1卷 第3期   页码 346-349 doi: 10.1007/s11465-006-0032-0

摘要： Due to complicated barriers, it is difficult to track the path of the mowing robot and to avoid barriers. In order to solve the problem, a method based on distance-measuring sensors and fuzzy control inputs was proposed. Its track

关键词： control     distance-measuring     problem     complicated     difficult    

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Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

《化学科学与工程前沿（英文）》 2015年 第9卷 第1期   页码 1-14 doi: 10.1007/s11705-015-1509-3

摘要： With the development of modern technology like high throughput screening, combinatorial chemistry and computer aid drug design, the drug discovery process has been dramatically accelerated. However, new drug candidates often exhibit poor aqueous or even organic medium solubility. Additionally, many of them may have low dissolution velocity and low oral bioavailability. Nanocrystal formulation sheds new light on advanced drug development. Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the comprehensive review of different technologies and methods in drug nanocrystal preparation, suspension, and stabilization, we will also compare nano- and micro-sized drug crystals in pharmaceutical applications and discuss current nanocrystal drugs on the market and their limitations.

关键词： drug nanocrystal     nanotechnology     formulation     bioavailability     stabilizers     drug delivery    

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IoT sensor-based BIM system for smart safety barriers of hazardous energy in petrochemical construction

《工程管理前沿（英文）》 2022年 第9卷 第1期   页码 1-15 doi: 10.1007/s42524-021-0160-6

摘要： The accidental release of hazardous energy is one of the causes of construction site accidents. This risk is considerably increased during petrochemical plant construction because the project itself is complex in terms of process, equipment, and environment. In addition, a general construction safety barrier hardly isolates and controls site hazardous energy effectively. Thus, this study proposes an Internet of Things (IoT) sensor-based building information modeling (BIM) system, which can be regarded as a new smart barrier design method for hazardous energy in petrochemical construction. In this system, BIM is used to support the identification of on-site hazardous energy, whereas IoT is used to collect the location of on-site personnel in real time. A hazardous energy isolation rule is defined to enable the system to generate a smart barrier on the web terminal window, thereby ensuring the safety of on-site person. This system has been applied to a large-scale construction project in Sinopec for one year and accumulated substantial practical data, which supported the idea about the application of sensor and BIM technology in construction. The related effects of the system on hazardous energy management are also presented in this work.

关键词： IoT     BIM     smart safety barrier     hazardous energy management     petrochemical construction    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

《化学科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 225-232 doi: 10.1007/s11705-014-1429-7

摘要： Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

关键词： controlled release     drug delivery     semi-solids     polymer     excipient    

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Cleaning the energy sources for water heating among Nanjing households: barriers and opportunities for

Lingyun ZHU,Beibei LIU,Jun BI

《环境科学与工程前沿（英文）》 2014年 第8卷 第5期   页码 757-766 doi: 10.1007/s11783-013-0603-3

摘要： Energy for water heating accounts for an increasing part in residential energy demand in China. An extensive survey was conducted to analyze the determinants of household energy choices for water heaters among residents in Nanjing, China. Two sets of variables were examined as potential influences: building features and household socio-economic characteristics. Results suggest that building features such as gas availability and building structures, and household characteristics such as household head’s education degree and energy-conserving sense are crucial determinants in choosing natural gas as water heater energy. Installation permission for solar water heater, building stories, and residential location serve as determining factors in choosing solar water heaters. Based on these, barriers and opportunities are discussed for transitions toward cleaner water heating energies, and suggestions are given for local governments to promote cleaner energy replacement in China.

关键词： residential energy demand     water heating     multinomial logit model    

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Implementation of total Lagrangian formulation for the elasto-plastic analysis of plane steel frames

Bing XIA, Yuching WU, Zhanfei HUANG

《结构与土木工程前沿（英文）》 2012年 第6卷 第3期   页码 257-266 doi: 10.1007/s11709-012-0163-9

摘要： In this paper, the co-rotational total Lagrangian forms of finite element formulations are derived to perform elasto-plastic analysis for plane steel frames that either experience increasing external loading at ambient temperature or constant external loading at elevated temperatures. Geometric nonlinearities and thermal-expansion effects are considered. A series of programs were developed based on these formulations. To verify the accuracy and efficiency of the nonlinear finite element programs, numerical benchmark tests were performed, and the results from these tests are in a good agreement with the literature. The effects of the nonlinear terms of the stiffness matrices on the computational results were investigated in detail. It was also demonstrated that the influence of geometric nonlinearities on the incremental steps of the finite element analysis for plane steel frames in the presence of fire is limited.

关键词： co-rotational     total Lagrangian     geometrical nonlinearity     fire     elasto-plastic    

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Continuous amino-functionalized University of Oslo 66 membranes as efficacious polysulfide barriers for

《化学科学与工程前沿（英文）》 2023年 第17卷 第2期   页码 194-205 doi: 10.1007/s11705-022-2206-7

摘要： The shuttle effect of soluble polysulfides is a serious problem impeding the development of lithium−sulfur batteries. Herein, continuous amino-functionalized University of Oslo 66 membranes supported on carbon nanotube films are proposed as ion-permselective interlayers that overcome these issues and show outstanding suppression of the polysulfide shuttle effect. The proposed membrane material has appropriately sized pores, and can act as ionic sieves and serve as barriers to polysulfides transport while allowing the passage of lithium ions during electrochemical cycles, thereby validly preventing the shuttling of polysulfides. Moreover, a fast catalytic conversion of polysulfides is also achieved with the as-developed interlayer. Therefore, lithium−sulfur batteries with this interlayer show a desirable initial capacity of 999.21 mAh·g–1 at 1 C and a durable cyclic stability with a decay rate of only 0.04% per cycle over 300 cycles. Moreover, a high area capacity of 4.82 mAh·cm–2 is also obtained even under increased sulfur loading (5.12 mg·cm–2) and a lean-electrolyte condition (E/S = 4.8 μL·mg–1).

关键词： lithium−sulfur batteries     amino-functionalized University of Oslo 66 membrane     polysulfide     interlayer    

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A novel finite element formulation for static bending analysis of functionally graded porous sandwich

Van Chinh NGUYEN; Trung Thanh TRAN; Trung NGUYEN-THOI; Quoc-Hoa PHAM

《结构与土木工程前沿（英文）》 2022年 第16卷 第12期   页码 1599-1620 doi: 10.1007/s11709-022-0891-4

摘要： This article aims to propose a finite element formulation based on Quasi-3D theory for the static bending analysis of functionally graded porous (FGP) sandwich plates. The FGP sandwich plates consist of three layers including the bottom skin of homogeneous metal, the top skin of fully ceramic and the FGP core layer with uneven porosity distribution. A quadrilateral (Q4) element with nine degrees of freedom (DOFs) per node is derived and employed in analyzing the static bending response of the plate under uniform and/or sinusoidally distributed loads. The accuracy of the present finite element formulation is verified by comparing the obtained numerical results with the published results in the literature. Then, some numerical examples are performed to examine the effects of the parameters including power-law index k and porosity coefficient ξ on the static bending response of rectangular FGP sandwich plates. In addition, a problem with a complicated L-shape model is conducted to illustrate the superiority of the proposed finite element method.

关键词： sandwich plates     functionally graded porous     static bending     Quasi-3D theory     Q4 element    

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Drivers and barriers to engage enterprises in environmental management initiatives in Suzhou Industrial

Bing ZHANG, Jun BI, Beibei LIU

《环境科学与工程前沿（英文）》 2009年 第3卷 第2期   页码 210-220 doi: 10.1007/s11783-009-0014-7

摘要： Small- and medium-sized enterprises (SMEs) play an important role in sustainable development not only for their significant contribution to China’s economy, but also for their big share of total discharged pollutants. Therefore, this research takes the enterprises in Suzhou Industrial Park, China as the case study to investigate the environmental management practices of SMEs, and identify drivers and barriers to engaging businesses in environmental management initiatives. It is shown that, as in other countries, SMEs are less active in adopting environmental management initiatives than larger companies. Legislation remains the key driver to engage SMEs in environmental management initiatives. Based on the analysis, policy recommendations are also presented.

关键词： small- and medium-sized enterprises (SMEs)     environmental management initiative     Suzhou industrial park    

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Barriers and countermeasures in developing traditional Chinese medicine in Europe

null

《医学前沿（英文）》 2016年 第10卷 第3期   页码 360-376 doi: 10.1007/s11684-016-0455-x

摘要：

Traditional Chinese medicine (TCM) is one of the unique cultural treasures of Chinese; it represents a significant feature and prominent advantage of the healthcare cause in China. Data in this paper were from World Health Organization, Chinese Bureau of Statistics, China National Knowledge Infrastructure, and PubMed. In recent years, TCM has established a solid foundation in Europe, which made great strides in legislation, education, research, and international exchange, and has enjoyed a vast development space in the continent. Now, TCM is embracing unprecedented development opportunities in Europe. At the same time, the stiff international competition poses a grave threat to China’s TCM industry. With multiple cultural, legal, and institutional challenges, as well as talent shortages in the way, TCM is now facing many difficulties in Europe. To fully prepare and enact active and vigorous steps to seize opportunities, we should have a clear picture about the serious challenges hampering TCM development in Europe. The TCM development at overseas markets has shifted from a spontaneous trade activity into a national strategy spearheaded by the government and participated in by multiple stakeholders. We should make a systematic, comprehensive, and sustainable push in fields such as TCM therapy, healthcare, education, research, culture, and industry development. The ultimate goal is to bring TCMs to the global market and allow them to play a role in safeguarding public health along with modern medicines.

关键词： traditional Chinese medicine     Europe     development    

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IMPROVING NITROGEN SAFETY IN CHINA: NITROGEN FLOWS, POLLUTION AND CONTROL

《农业科学与工程前沿（英文）》 2022年 第9卷 第3期   页码 465-474 doi: 10.15302/J-FASE-2022454

摘要：

● It is necessary to address the N flows and their impacts on environment in China for sustainable N management.

关键词： barriers     future management     ammonia emissions     nitrogen input     water N pollution    

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Robust isogeometric topology optimization for piezoelectric actuators with uniform manufacturability

《机械工程前沿（英文）》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0683-5

摘要： Piezoelectric actuators have received substantial attention among the industry and academia due to quick responses, such as high output force, high stiffness, high accuracy, and precision. However, the design of piezoelectric actuators always suffers from the emergence of several localized hinges with only one-node connection, which have difficulty satisfying manufacturing and machining requirements (from the over- or under-etching devices). The main purpose of the current paper is to propose a robust isogeometric topology optimization (RITO) method for the design of piezoelectric actuators, which can effectively remove the critical issue induced by one-node connected hinges and simultaneously maintain uniform manufacturability in the optimized topologies. In RITO, the isogeometric analysis replacing the conventional finite element method is applied to compute the unknown electro elastic fields in piezoelectric materials, which can improve numerical accuracy and then enhance iterative stability. The erode–dilate operator is introduced in topology representation to construct the eroded, intermediate, and dilated density distribution functions by non-uniform rational B-splines. Finally, the RITO formulation for the design of piezoelectric materials is developed, and several numerical examples are performed to test the effectiveness and efficiency of the proposed RITO method.

关键词： piezoelectric actuator     isogeometric topology optimization     uniform manufacturability     robust formulation     density distribution function    

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Controlling interstory drift ratio profiles via topology optimization strategies

《结构与土木工程前沿（英文）》 2023年 第17卷 第2期   页码 165-178 doi: 10.1007/s11709-022-0892-3

摘要： An approach to control the profiles of interstory drift ratios along the height of building structures via topology optimization is proposed herein. The theoretical foundation of the proposed approach involves solving a min–max optimization problem to suppress the maximum interstory drift ratio among all stories. Two formulations are suggested: one inherits the bound formulation and the other utilizes a p-norm function to aggregate all individual interstory drift ratios. The proposed methodology can shape the interstory drift ratio profiles into inverted triangular or quadratic patterns because it realizes profile control using a group of shape weight coefficients. The proposed formulations are validated via a series of numerical examples. The disparity between the two formulations is clear. The optimization results show the optimal structural features for controlling the interstory drift ratios under different requirements.

关键词： interstory drift ratio     aggregation function     bound formulation     min–max problem     topology optimization    

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标题 作者 时间 类型 操作

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

期刊论文

Understanding barriers to BIM implementation: Their impact across organizational levels in relation to

Sander SIEBELINK, Hans VOORDIJK, Maaike ENDEDIJK, Arjen ADRIAANSE

期刊论文

Avoiding barriers in control of mowing robot

QIU Bai-jing, QIAN Guo-hong, XIANG Zhong-ping, LI Zuo-peng

期刊论文

Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

期刊论文

IoT sensor-based BIM system for smart safety barriers of hazardous energy in petrochemical construction

期刊论文

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

期刊论文

Cleaning the energy sources for water heating among Nanjing households: barriers and opportunities for

Lingyun ZHU,Beibei LIU,Jun BI

期刊论文

Implementation of total Lagrangian formulation for the elasto-plastic analysis of plane steel frames

Bing XIA, Yuching WU, Zhanfei HUANG

期刊论文

Continuous amino-functionalized University of Oslo 66 membranes as efficacious polysulfide barriers for

期刊论文

A novel finite element formulation for static bending analysis of functionally graded porous sandwich

Van Chinh NGUYEN; Trung Thanh TRAN; Trung NGUYEN-THOI; Quoc-Hoa PHAM

期刊论文

Drivers and barriers to engage enterprises in environmental management initiatives in Suzhou Industrial

Bing ZHANG, Jun BI, Beibei LIU

期刊论文

Barriers and countermeasures in developing traditional Chinese medicine in Europe

null

期刊论文

IMPROVING NITROGEN SAFETY IN CHINA: NITROGEN FLOWS, POLLUTION AND CONTROL

期刊论文

Robust isogeometric topology optimization for piezoelectric actuators with uniform manufacturability

期刊论文

Controlling interstory drift ratio profiles via topology optimization strategies

期刊论文